Emidio Capriotti emidio.capriotti@gmail.com emidio.capriotti@uib.es

I am a Marie Curie IOF researcher in the Structural Bioinformatics Unit at the University of Balearic Islands (UIB) in Palma de Mallorca (Spain). During the outgoung phase I was postdoctoral researcher at the Helix Group in the Bioengineering Department at Stanford University. I was also postdoc for 2 years at the University of Bologna in the Biocomputing Group and 3 years in the Structural Bioinformatics Unit at CIPF of Valencia (Spain).
My scientific background is in Structural Bioinformatics but in the last years my research activity moved toward the study of the effect of SNPs resulting in single amino acid polymorphisms. The study of the mechanism that governs the formation of the protein three-dimensional has been applied to predict the effect of single point protein mutations on the protein stability. I developed different machine learning methods to evaluate the free energy change due to a given single amino acid polymorphisms (SAPs). More recently, I have been interested to study the relationship between SAPs and the insurgence of human disease. Using information derived from the protein sequence and from the sequence profile, I implemented web server tools to predict if a given mutation can be classified as disease-related or not. During the last years, I have focused my attention on a subset of mutations related to specific disease like cancer and diabetes. I am interested to design new disease-specific algorithms and more in general new tools for the Personal Genomics.
The final goal of my research activity is the understanding of the relationship between mutation and disease using the increasing number of data derived from high-throughput techniques. For more details about my scientific activity download my CV.